ZOLOFT is extensively metabolized by the liver. In patients with chronic mild liver impairment, sertraline clearance was reduced, resulting in increased AUC, Cmax and elimination half-life.
Can Zoloft cause liver damage?
Rare instances of acute liver failure have been attributed to sertraline therapy. Rechallenge usually results in recurrence of liver injury and should be avoided. Persons with intolerance to sertraline may have similar reactions to other SSRIs and careful monitoring is warranted if other such agents are used.
Where is Zoloft absorbed?
Sertraline is slowly absorbed following oral administration and undergoes extensive first-pass oxidation to form N-desmethyl-sertraline, a weakly active metabolite that accumulates to a greater concentration in plasma than the parent drug at steady state.
Why was Zoloft taken off the market?
Zoloft Lawsuits. Zoloft lawsuits claimed Pfizer, the drug’s manufacturer, failed to warn consumers that its popular antidepressant caused birth defects. A series of unfavorable rulings has led to the dismissal or withdrawal of hundreds of Zoloft lawsuits.
Can Zoloft cause kidney problems?
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse.
Which antidepressant is easiest on the liver?
The antidepressants that seem to have the least potential for hepatotoxicity are citalopram, escitalopram, paroxetine, and fluvoxamine.
Can Zoloft cause elevated ALT?
Data from the premarketing evaluation of sertraline hydrochloride suggest that the rate of asymptomatic elevations in serum transaminases (AST and ALT) secondary to sertraline use is 0.8%, with most cases occurring within the first 9 weeks of drug initiation.
How long does it take Zoloft to metabolize?
Plasma concentrations are linearly related to dose. The elimination half-life is about 32 h; metabolism is by demethylation to an inactive metabolite. Once-daily dosing is recommended, with steady state being reached after about 7 days.
How long does it take Zoloft to get out of your system?
Zoloft has a half-life of about one day. That means that for every day that passes without taking the medication, the level in the blood falls by 50 percent. After one day, the level is reduced to 50 percent of the original level, after two days to 25 percent, after three days to 12.5 percent, and so on.
How long does it take to digest Zoloft?
In general, it typically takes approximately 30 minutes for most medications to dissolve. When a medication is coated in a special coating – which may help protect the drug from stomach acids – often times it may take longer for the therapeutic to reach the bloodstream.
What is Zoloft black box warning?
The United States Food and Drug Administration issued a Black Box warning in October 2004 after placebo-controlled trials of antidepressant medications found an increased risk of suicidal thoughts and behaviors among children and adolescents taking antidepressant medications relative to placebo.
What is a good replacement for Zoloft?
Top 5 Zoloft alternatives
- Lexapro. Zoloft and Lexapro are both SSRIs indicated for the treatment of depression. …
- Prozac. Prozac is another SSRI medication that works in the same way as Zoloft to increase serotonin activity. …
- Effexor. …
- Cymbalta. …
How much money did Pfizer make from Zoloft?
Meanwhile, antidepressants account for second, third and fourth place by script numbers last year. Pfizer’s Zoloft, and its copycat forms, accounted for 41.4 million scripts last year, an 11% increase over 2011. For Pfizer, the brand managed to bring in $469 million in sales, more than many of its newer drugs.
Are antidepressants hard on your kidneys?
A: Any medication, if taken without consultation with your physician, can cause kidney damage. It is frequently combinations of medication, both prescribed and over the counter that cause kidney damage.
Does SSRI cause kidney problems?
Increased bleeding risk was reported in association with serotonin-selective reuptake inhibitors (SSRIs),29 which may become problematic in advanced CKD and underlying platelet dysfunction related to uremia.
What antidepressants can you take with kidney disease?
Many older patients have chronic kidney disease (CKD), and a lower dose of anti-depressants paroxetine, mirtazapine and venlafaxine is recommended in patients with CKD to prevent drug accumulation from reduced elimination.